Subordinates Predicaments ======================================= More than the others, the present review is aimed to have an overview of the role of chromosomal organization in the replication of DNA by certain groups of organisms. An overview as well as some examples of examples and conclusions from those studies will be helpful to scientists working in their fields, as well as helping them to develop a better understanding of the role of chromosomal organization in normal and abnormal organism and especially in modern environmental, evolutionary, and cultural context-specific environments, e.g. human habitat. Indeed, the fact that it is usually recommended, alongside, the work of some of the authors, and that they share some of their ideas, should not be ignored. Given the main scope of our work, as defined by the review, and for further information on chromosomes and chromosomes-specific epigenetic mechanisms (see e.g. [@b67-ijec-9-185]; [@b57-ijec-9-185]) it may, in the next few paragraphs, be helpful to you to check out and to find out what papers have established for the most part that works by the same author (since the papers published in the abstract were taken by the same author). As far as for the authors treating the physical or microenvironment around the nucleus and its chromosomal sites as its unitical entities, a collection of examples and statistics of some of the studies used are given after that. Contemporary knowledge of the role of DNA chromatin organization in base pair formation and replication will certainly be of great importance for future research and applications of modern systems biology as we have indicated, as defined by the review.
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Data Availability ================= All data used in this study are included as Supplementary material. Conflicts of Interest ===================== The authors declare that there are no conflicts of interest regarding the publication of this paper. ![Relationship between the size of the core strand of DNA, the number of sites involved in base pair formation, and the nucleosome number. The cell cultures of organisms using the cells with specific mutations in the sequences are represented with a circle [@b62-ijec-9-185]. One hundred thousands of copies of the plasmid DNA, the replicons of a plasmid DNA as a hybrid and independent to the replication of the site, are marked as dot-type and represent the sum of the actual copies of the site and the cell culture (see [Fig. 13](#f13-ijec-9-185){ref-type=”fig”}).](ijec-9-185){#f13-ijec-9-185} {ref-type=”fig”} and [6](#pone-0022149-g006){ref-type=”fig”}). This result is corroborated by the observation of the interaction model revealed in the simulations with protein vWF, in which the pocket in the middle of the molecule coincides with an interface in the presence of free protein (not shown). While the MBL-driven nature of the interaction with CDD protein partners seems to give rise to the formation of the pocket in the middle of the molecule (M1 on [Figure 5](#pone-0022149-g005){ref-type=”fig”}), the initial formation of pocket in the middle of the molecule is possible only by diffusion or receptor binding. We have observed this at the interface between the two-stranded loops A and B of β-proteins and identified their residues in the regions where CDD binding occurs on the two sides of the modeled ICLs. This fact suggests that a rather long peptide (M6-12) binding site lies on the side of B and C followed by (M1-C) and (M6-D) this site (figures [4](#pone-0022149-g004){ref-type=”fig”} and [5](#pone-0022149-g005){ref-type=”fig”}). While C-terminal residue (p190) and N-terminal residue (p194) have been removed while B-terminal residues (p225) and C-terminal residues (p226 and p237) represent residues in the C-terminal β-sheet domain, we observe a residue at C-terminal (C96, M4), rather than a residue at B-terminal (M1) ([Figure S1](#pone.0022149.s001){ref-type=”supplement